Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques

Safety and Immunological Evaluation of Interleukin-21 Plus Anti-α4β7 mAb Combination Therapy in Rhesus Macaques

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections compromise gut immunological barriers, inducing high levels of inflammation and a severe depletion of intestinal CD4+ T cells. Expression of α4β7 integrin promotes homing of activated T cells to intestinal sites wh...

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Bibliographic Details
Main Authors: Maria Pino, Srijayaprakash Babu Uppada, Kabita Pandey, Colin King, Kevin Nguyen, Inbo Shim, Kenneth Rogers, Francois Villinger, Mirko Paiardini, Siddappa N. Byrareddy
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
anti-α4β7
IL-21
immune activation
T- cell homing
macaques
rhesus macaques
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01275/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01275/full

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