γδ T Cells May Aggravate Acute Graft-Versus-Host Disease Through CXCR4 Signaling After Allogeneic Hematopoietic Transplantation

γδ T Cells May Aggravate Acute Graft-Versus-Host Disease Through CXCR4 Signaling After Allogeneic Hematopoietic Transplantation

Graft-versus-host disease (GVHD) is a pathology in which chemokines and their receptors play essential roles in directing the migration of alloreactive donor T cells into GVHD organs, thereby leading to further target tissue damage. Currently, acute GVHD (aGVHD) remains a major cause of high morbidi...

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Bibliographic Details
Main Authors: Ning Wu, Ruoyang Liu, Shuang Liang, Haitao Gao, Lan-Ping Xu, Xiao-Hui Zhang, Jiangying Liu, Xiao-Jun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
acute graft-versus-host disease
γδ T cells
CXCR4
T cell migration
hematopoietic cell transplantation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.687961/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.687961/full

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