Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids

Synthesis, Leishmanicidal and Cytotoxic Activity of Triclosan-Chalcone, Triclosan-Chromone and Triclosan-Coumarin Hybrids

Twelve hybrids derived from triclosan were obtained via Williamson etherification of O-triclosan alkyl bromide plus chalcone and O-coumarin or O-chromone alkyl bromide plus triclosan, respectively. Structures of the products were elucidated by spectroscopic analysis. The synthesized compounds were e...

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Bibliographic Details
Main Authors: Elver Otero, Sebastián Vergara, Sara M. Robledo, Wilson Cardona, Miguel Carda, Ivan D. Vélez, Carlos Rojas, Felipe Otálvaro
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Molecules
Subjects:
leishmaniasis
antiprotozoal
triclosan
coumarin
chromone
chalcone
hybrids
Online Access:http://www.mdpi.com/1420-3049/19/9/13251

Internet

http://www.mdpi.com/1420-3049/19/9/13251

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