Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells

Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells

Background: KG-135, a standardized formulation enriched with Rk1, Rg3, and Rg5 ginsenosides, has been shown to inhibit various types of cancer cells; however, the underlying mechanisms are not fully understood. In this study, we explored its effects in A549 human lung cancer cells to investigate the...

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Bibliographic Details
Main Authors: Chih-Jung Yao, Jyh-Ming Chow, Shuang-En Chuang, Chia-Lun Chang, Ming-De Yan, Hsin-Lun Lee, I-Chun Lai, Pei-Chun Lin, Gi-Ming Lai
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Ginseng Research
Subjects:
autophagy
FOXO3a
ginsenoside
KG-135
lung cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845316300483

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http://www.sciencedirect.com/science/article/pii/S1226845316300483

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