Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)

Metabolic regulation of calcium pumps in pancreatic cancer: role of phosphofructokinase-fructose-bisphosphatase-3 (PFKFB3)

Abstract Background High glycolytic rate is a hallmark of cancer (Warburg effect). Glycolytic ATP is required for fuelling plasma membrane calcium ATPases (PMCAs), responsible for extrusion of cytosolic calcium, in pancreatic ductal adenocarcinoma (PDAC). Phosphofructokinase-fructose-bisphosphatase-...

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Bibliographic Details
Main Authors: D. A. Richardson, P. Sritangos, A. D. James, A. Sultan, J. I. E. Bruce
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Cancer & Metabolism
Subjects:
Metabolism
Glycolysis
PFKFB3
Calcium pumps
PMCA
Calcium overload
Online Access:http://link.springer.com/article/10.1186/s40170-020-0210-2

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http://link.springer.com/article/10.1186/s40170-020-0210-2

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