Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double‐blind, placebo‐controlled trial

Stem cell mobilization with plerixafor and healing of diabetic ischemic wounds: A phase IIa, randomized, double‐blind, placebo‐controlled trial

Abstract Bone marrow‐derived cells contribute to tissue repair, but traffic of hematopoietic stem/progenitor cells (HSPCs) is impaired in diabetes. We therefore tested whether HSPC mobilization with the CXCR4 antagonist plerixafor improved healing of ischemic diabetic wounds. This was a pilot, phase...

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Bibliographic Details
Main Authors: Benedetta Maria Bonora, Roberta Cappellari, Marta Mazzucato, Mauro Rigato, Marco Grasso, Mirko Menegolo, Andrea Bruttocao, Angelo Avogaro, Gian Paolo Fadini
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Stem Cells Translational Medicine
Subjects:
angiogenesis
CD34+
clinical translation
diabetes
hematopoietic stem cells
mobilization
Online Access:https://doi.org/10.1002/sctm.20-0020

Internet

https://doi.org/10.1002/sctm.20-0020

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