Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly via Low-Density Lipoprotein Receptor-Related Protein 1

Glypican 4 Regulates Aβ Internalization in Neural Stem Cells Partly via Low-Density Lipoprotein Receptor-Related Protein 1

Neural stem cell (NSC) damage has been reported in patients with Alzheimer’s disease. Intracellular Aβ plays a vital role in NSC damage. Heparan sulfate proteoglycans are potent mediators of Aβ enrichment in the brain. We hypothesized the heparan sulfate proteoglycan glypican 4 (Gpc4) regulates Aβ i...

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Bibliographic Details
Main Authors: Kaige Ma, Shan Xing, Yan Luan, Chenglin Zhang, Yingfei Liu, Yulang Fei, Zhichao Zhang, Yong Liu, Xinlin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
glypican 4
neural stem cells (NSCs)
low density lipoprotein receptor related protein 1
β-amyloid internalization
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.732429/full

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https://www.frontiersin.org/articles/10.3389/fncel.2021.732429/full

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