Beyond thrombosis: the impact of tissue factor signaling in cancer

Beyond thrombosis: the impact of tissue factor signaling in cancer

Abstract Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition t...

Full description

Bibliographic Details
Main Authors: Dusten Unruh, Craig Horbinski
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Hematology & Oncology
Subjects:
Tissue factor
Protease-activated receptors
Receptor tyrosine kinases
Integrins
Metastasis
Angiogenesis
Online Access:http://link.springer.com/article/10.1186/s13045-020-00932-z

Internet

http://link.springer.com/article/10.1186/s13045-020-00932-z

Similar Items