Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity.

Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity.

Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras by fusing FasL to domains of the Leukemia Inh...

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Bibliographic Details
Main Authors: Sophie Daburon, Christel Devaud, Pierre Costet, Aurore Morello, Laure Garrigue-Antar, Mike Maillasson, Nathalie Hargous, Delphine Lapaillerie, Marc Bonneu, Julie Dechanet-Merville, Patrick Legembre, Myriam Capone, Jean-François Moreau, Jean-Luc Taupin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3541234?pdf=render

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http://europepmc.org/articles/PMC3541234?pdf=render

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