The Role of Two-Pore Channels in Norepinephrine-Induced [Ca<sup>2+</sup>]<sub>i</sub> Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction

The Role of Two-Pore Channels in Norepinephrine-Induced [Ca<sup>2+</sup>]<sub>i</sub> Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction

Second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) triggers Ca<sup>2+</sup> release via two-pore channels (TPCs) localized in endolysosomal vesicles. The aim of the present work is to evaluate the role of TPCs in the action of norepinephrine (NE), angiotensin II (AngI...

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Bibliographic Details
Main Authors: Sergei K. Trufanov, Elena Yu. Rybakova, Piotr P. Avdonin, Alexandra A. Tsitrina, Irina L. Zharkikh, Nikolay V. Goncharov, Richard O. Jenkins, Pavel V. Avdonin
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
norepinephrine
calcium
two-pore channels
smooth muscle cells
ned 19
naadp
sirna
aorta
Online Access:https://www.mdpi.com/2073-4409/8/10/1144

Internet

https://www.mdpi.com/2073-4409/8/10/1144

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