Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling

Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling

Abstract Background Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). However, its regulatory mechanism in OC and whether TGF-β1 is involved in chemosensitivity regulation remains unclear...

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Bibliographic Details
Main Authors: Yanqiu Wang, Jun Xiang, Jianjun Wang, Yazhong Ji
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Biological Research
Subjects:
Ovarian cancer
TGF-β1
BRCA1
Smad3
Proliferation
Online Access:http://link.springer.com/article/10.1186/s40659-018-0205-4

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http://link.springer.com/article/10.1186/s40659-018-0205-4

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