Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor

Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor

Preservation of the excitability of spiral ganglion neurons (SGN) may contribute to an improved speech perception after cochlear implantation. Thus, the application of exogenous neurotrophic factors such as the neurotrophin brain-derived neurotrophic factor (BDNF) to increase SGN survival in vitro a...

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Bibliographic Details
Main Authors: Jennifer Harre, Laura Heinkele, Melanie Steffens, Athanasia Warnecke, Thomas Lenarz, Ingo Just, Astrid Rohrbeck
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
spiral ganglion neurons
RhoA
C3 exoenzyme
brain-derived neurotrophic factor
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.602897/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.602897/full

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