Functional Analyses of Four <i>CYP1A1</i> Missense Mutations Present in Patients with Atypical Femoral Fractures

Functional Analyses of Four <i>CYP1A1</i> Missense Mutations Present in Patients with Atypical Femoral Fractures

Osteoporosis is the most common metabolic bone disorder and nitrogen-containing bisphosphonates (BP) are a first line treatment for it. Yet, atypical femoral fractures (AFF), a rare adverse effect, may appear after prolonged BP administration. Given the low incidence of AFF, an underlying genetic ca...

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Bibliographic Details
Main Authors: Nerea Ugartondo, Núria Martínez-Gil, Mònica Esteve, Natàlia Garcia-Giralt, Neus Roca-Ayats, Diana Ovejero, Xavier Nogués, Adolfo Díez-Pérez, Raquel Rabionet, Daniel Grinberg, Susanna Balcells
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
CYP1A1
osteoporosis
atypical femoral fractures
bisphosphonates
Online Access:https://www.mdpi.com/1422-0067/22/14/7395

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https://www.mdpi.com/1422-0067/22/14/7395

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