Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq

Triple-negative breast cancer is highly heterogeneous and aggressive. Here, the authors utilise single-cell RNA sequencing to investigate this heterogeneity, and discover a subpopulation of cells associated with metastasis and treatment resistance signatures, and linked to long term survival outcome...

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Bibliographic Details
Main Authors: Mihriban Karaayvaz, Simona Cristea, Shawn M. Gillespie, Anoop P. Patel, Ravindra Mylvaganam, Christina C. Luo, Michelle C. Specht, Bradley E. Bernstein, Franziska Michor, Leif W. Ellisen
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06052-0

Internet

https://doi.org/10.1038/s41467-018-06052-0

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