Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model

Neutralizing Concentrations of Anti-Botulinum Toxin Antibodies Positively Correlate with Mouse Neutralization Assay Results in a Guinea Pig Model

Botulinum neurotoxins (BoNT) are some of the most toxic proteins known and can induce respiratory failure requiring long-term intensive care. Treatment of botulism includes the administration of antitoxins. Monoclonal antibodies (mAbs) hold considerable promise as BoNT therapeutics and prophylactics...

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Bibliographic Details
Main Authors: Milan T. Tomic, Shauna Farr-Jones, Emily S. Syar, Nancy Niemuth, Dean Kobs, Michael J. Hackett, Yero Espinoza, Zacchary Martinez, Khanh Pham, Doris M. Snow, James D. Marks, Ronald R. Cobb
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Toxins
Subjects:
botulinum neurotoxin
botulism
aerosol
monoclonal antibody (mAb)
guinea pig inhalation model
oligoclonal antibody
Online Access:https://www.mdpi.com/2072-6651/13/9/671

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https://www.mdpi.com/2072-6651/13/9/671

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