The Formin mDia1 Regulates Acute Lymphoblastic Leukemia Engraftment, Migration, and Progression in vivo

The Formin mDia1 Regulates Acute Lymphoblastic Leukemia Engraftment, Migration, and Progression in vivo

Leukemias typically arise in the bone marrow and then spread to the blood and into other tissues. To disseminate into tissues, leukemia cells migrate into the blood stream and then exit the circulation by migrating across vascular endothelial barriers. Formin proteins regulate cytoskeletal remodelin...

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Bibliographic Details
Main Authors: Scott B. Thompson, Eric J. Wigton, Sai Harsha Krovi, Jeffrey W. Chung, Robert A. Long, Jordan Jacobelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Oncology
Subjects:
leukemia engraftment
transendothelial migration
cytoskeleton
formins
mDia1
Diaph1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00389/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00389/full

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