Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5’ Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis

Genetic and Epigenetic Modification of Rat Liver Progenitor Cells via HNF4α Transduction and 5’ Azacytidine Treatment: An Integrated miRNA and mRNA Expression Profile Analysis

Neonatal liver-derived rat epithelial cells (rLEC) from biliary origin are liver progenitor cells that acquire a hepatocyte-like phenotype upon sequential exposure to hepatogenic growth factors and cytokines. Undifferentiated rLEC express several liver-enriched transcription factors, including the h...

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Bibliographic Details
Main Authors: Jennifer Bolleyn, Matthias Rombaut, Nisha Nair, Steven Branson, Anja Heymans, Marinee Chuah, Thierry VandenDriessche, Vera Rogiers, Joery De Kock, Tamara Vanhaecke
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Genes
Subjects:
liver-enriched transcription factor
azacytidine
microRNA
liver progenitor cell
lentiviral transduction
gene expression
Online Access:https://www.mdpi.com/2073-4425/11/5/486

Internet

https://www.mdpi.com/2073-4425/11/5/486

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