Use of a failure probability constraint to suggest an initial dose in a phase I cancer clinical trial
The primary objective of a Phase I cancer clinical trial is to determine the maximum tolerated dose of a drug. The “failure probability” was proposed and used as a constraint to help identify a suitable initial dose range. The maximum tolerated dose was then determined based on a 3 + 3 cohort-based...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-12-01
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| Series: | Journal of Food and Drug Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1021949814000295 |