Genetically modified T cells in cancer therapy: opportunities and challenges

Genetically modified T cells in cancer therapy: opportunities and challenges

Tumours use many strategies to evade the host immune response, including downregulation or weak immunogenicity of target antigens and creation of an immune-suppressive tumour environment. T cells play a key role in cell-mediated immunity and, recently, strategies to genetically modify T cells either...

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Bibliographic Details
Main Authors: Michaela Sharpe, Natalie Mount
Format: Article
Language:English
Published: The Company of Biologists 2015-04-01
Series:Disease Models & Mechanisms
Subjects:
Immunotherapies
Gene modification
TCR
CAR
T cell
Oncology
Efficacy
Safety
Regulation
Manufacturing
Clinical trial
Online Access:http://dmm.biologists.org/content/8/4/337

Internet

http://dmm.biologists.org/content/8/4/337

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