A Role for Timp3 in Microbiota-Driven Hepatic Steatosis and Metabolic Dysfunction

A Role for Timp3 in Microbiota-Driven Hepatic Steatosis and Metabolic Dysfunction

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The effect of gut microbiota on obesity and insulin resistance is now recognized, but the underlying host-dependent mechanisms remain poorly undefined. We find that tissue inhibitor of metalloproteinase 3 knockout (Timp3−/−) mice fed a high-fat diet exhibit gut microbiota dysbiosis, an increase in b...

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Bibliographic Details
Main Authors: Maria Mavilio, Valentina Marchetti, Marta Fabrizi, Robert Stöhr, Arianna Marino, Viviana Casagrande, Loredana Fiorentino, Marina Cardellini, Ben Kappel, Ivan Monteleone, Celine Garret, Alessandro Mauriello, Giovanni Monteleone, Alessio Farcomeni, Remy Burcelin, Rossella Menghini, Massimo Federici
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716307677

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http://www.sciencedirect.com/science/article/pii/S2211124716307677

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