Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry

Peptide Triazole Thiol Irreversibly Inactivates Metastable HIV-1 Env by Accessing Conformational Triggers Intrinsic to Virus–Cell Entry

KR13, a peptide triazole thiol previously established to inhibit HIV-1 infection and cause virus lysis, was evaluated by flow cytometry against JRFL Env-presenting cells to characterize induced Env and membrane transformations leading to irreversible inactivation. Transiently transfected HEK293T cel...

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Bibliographic Details
Main Authors: Charles Gotuaco Ang, Erik Carter, Ann Haftl, Shiyu Zhang, Adel A. Rashad, Michele Kutzler, Cameron F. Abrams, Irwin M. Chaiken
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Microorganisms
Subjects:
HIV-1
Env
metastability
flow cytometry
entry inhibition
membrane poration
Online Access:https://www.mdpi.com/2076-2607/9/6/1286

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https://www.mdpi.com/2076-2607/9/6/1286

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