Patient‐derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR‐T cells in vitro

Patient‐derived organoids of bladder cancer recapitulate antigen expression profiles and serve as a personal evaluation model for CAR‐T cells in vitro

Abstract Objectives Recent advances in patient‐derived cancer organoids have opened a new avenue for personalised medicine. We aimed to establish an in vitro technological platform to evaluate chimeric antigen receptor (CAR)‐T cell‐mediated cytotoxicity against bladder cancer. Methods Patient‐derive...

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Bibliographic Details
Main Authors: Lei Yu, Zhichao Li, Hongbin Mei, Wujiao Li, Dong Chen, Lisa Liu, Zhongfu Zhang, Yangyang Sun, Fei Song, Wei Chen, Weiren Huang
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
bladder cancer
CAR‐T
cytotoxicity evaluation
MUC1
organoid
Online Access:https://doi.org/10.1002/cti2.1248

Internet

https://doi.org/10.1002/cti2.1248

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