Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice

Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice

Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (AD). A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid β-protein (Aβ), self-associates to form soluble assemblies loosely referred to as “oligomers” and that these are...

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Bibliographic Details
Main Authors: Alexandra J. Mably, Wen Liu, Jessica M. Mc Donald, Jean-Cosme Dodart, Frédérique Bard, Cynthia A. Lemere, Brian O'Nuallain, Dominic M. Walsh
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid β-protein
Immunotherapy
Oligomers
APP transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300127

Internet

http://www.sciencedirect.com/science/article/pii/S0969996115300127

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