Systematic Evaluation of Structure-Activity Relationships of the Riminophenazine Class and Discovery of a C2 Pyridylamino Series for the Treatment of Multidrug-Resistant Tuberculosis

Systematic Evaluation of Structure-Activity Relationships of the Riminophenazine Class and Discovery of a C2 Pyridylamino Series for the Treatment of Multidrug-Resistant Tuberculosis

Clofazimine, a member of the riminophenazine class of drugs, is the cornerstone agent for the treatment of leprosy. This agent is currently being studied in clinical trials for the treatment of multidrug-resistant tuberculosis to address the urgent need for new drugs that can overcome existing and e...

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Bibliographic Details
Main Authors: Haihong Huang, Dali Yin, Chun Li, Bin Wang, Gang Zhang, Zhenkun Ma, Fei Wang, Chen Ma, Meiqin Zheng, Xuan Li, Yu Lu, Dongfeng Zhang, Tianming Yang, Kai Liu, Binna Liu
Format: Article
Language:English
Published: MDPI AG 2012-04-01
Series:Molecules
Subjects:
anti-tuberculosis
MDR-TB
riminophenazine
clofazimine
skin pigmentation
Online Access:http://www.mdpi.com/1420-3049/17/4/4545/

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http://www.mdpi.com/1420-3049/17/4/4545/

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