Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation

Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation

Large granular lymphocyte (LGL) leukemia arises spontaneously in elderly Fischer (F344) rats. This rodent model has been shown to emulate many aspects of the natural killer (NK) variant of human LGL leukemia. Previous transplantation of leukemic material into young F344 rats resulted in several stra...

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Bibliographic Details
Main Authors: T. Tiffany Wang, Jun Yang, Shubha Dighe, Matthew W. Schmachtenberg, Nathan T. Leigh, Emily Farber, Suna Onengut-Gumuscu, David J. Feith, Aakrosh Ratan, Thomas P. Loughran, Thomas L. Olson
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
jak/stat
leukemia
mutation
rnk-16
f344
nk cells
activation
Online Access:https://www.mdpi.com/2072-6694/12/1/126

Internet

https://www.mdpi.com/2072-6694/12/1/126

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