Molecular Determinants of Brevetoxin Binding to Voltage-Gated Sodium Channels

Brevetoxins are produced by dinoflagellates such as <i>Karenia brevis</i> in warm-water red tides and cause neurotoxic shellfish poisoning. They bind to voltage-gated sodium channels at neurotoxin receptor 5, making the channels more active by shifting the voltage-dependence of activatio...

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Bibliographic Details
Main Authors: Keiichi Konoki, Daniel G. Baden, Todd Scheuer, William A. Catterall
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/11/9/513