Retinoic Acid Induces Functionally Suppressive Foxp3+RORγt+ T Cells In Vitro

IntroductionCD4+ T cells with regulatory function co-expressing Foxp3 and RORγt are linked to the development of oral tolerance towards innocuous food antigens in mice. This study aimed to discern the role played by IL-6 and retinoic acid (RA) in the in vitro generation of Foxp3+RORγt+ T cells and t...

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Bibliographic Details
Main Authors: Mónica Martínez-Blanco, Daniel Lozano-Ojalvo, Leticia Pérez-Rodríguez, Sara Benedé, Elena Molina, Rosina López-Fandiño
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.675733/full