Turmerone enriched standardized Curcuma longa extract alleviates LPS induced inflammation and cytokine production by regulating TLR4–IRAK1–ROS–MAPK–NFκB axis

Turmerone enriched standardized Curcuma longa extract alleviates LPS induced inflammation and cytokine production by regulating TLR4–IRAK1–ROS–MAPK–NFκB axis

In the present study turmerone enriched curcuma oil (C.oil) obtained from Curcuma longa L. was evaluated in lipopolysaccharide (LPS) induced inflammation in THP-1 human monocytes, J774.2 murine macrophages and Swiss mice. THP-1, J774.2 and mice or human whole blood pre-treated with C.oil (1–30 µg/ml...

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Bibliographic Details
Main Authors: Minakshi Rana, Sukka Santosh Reddy, Preeti Maurya, Vishal Singh, Saurabh Chaturvedi, Kamalpreet Kaur, Heena Agarwal, Hafsa Ahmad, Arshi Naqvi, Anil Kumar Dwivedi, Madhu Dikshit, Manoj Kumar Barthwal
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Journal of Functional Foods
Subjects:
Curcuma oil
Endotoxemia
IRAK1
Endothelial dysfunction
Oxidative stress
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464615002078

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http://www.sciencedirect.com/science/article/pii/S1756464615002078

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