Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation

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Summary: The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide T cell antigen receptor (pMHC)-induced signaling not explicable by enhanced ligand binding, lateral diffusion, clusterin...

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Bibliographic Details
Main Authors: Anna-Lisa Lanz, Giulia Masi, Nicla Porciello, André Cohnen, Deborah Cipria, Dheeraj Prakaash, Štefan Bálint, Roberto Raggiaschi, Donatella Galgano, David K. Cole, Marco Lepore, Omer Dushek, Michael L. Dustin, Mark S.P. Sansom, Antreas C. Kalli, Oreste Acuto
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Cell Reports
Subjects:
adaptive immunity
T cell activation
T cell antigen receptor
membrane signalling
allosteric mechanism
molecular dynamics simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721007737

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http://www.sciencedirect.com/science/article/pii/S2211124721007737

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