PABPN1-Dependent mRNA Processing Induces Muscle Wasting.

PABPN1-Dependent mRNA Processing Induces Muscle Wasting.

Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles. An expansion mutation in PABPN1 is the genetic cause of oculopharyngeal muscle dystrophy (OPMD), a late onset and rare myopathy. Moreover, re...

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Bibliographic Details
Main Authors: Muhammad Riaz, Yotam Raz, Maaike van Putten, Guillem Paniagua-Soriano, Yvonne D Krom, Bogdan I Florea, Vered Raz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4859507?pdf=render

Internet

http://europepmc.org/articles/PMC4859507?pdf=render

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