Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma

Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma

Macrophage migration inhibitory factor (MIF) has been shown to promote disease progression in many malignancies, including multiple myeloma (MM). We previously reported that MIF regulates MM bone marrow homing and knockdown of MIF favors the extramedullary myeloma formation in mice. Here, based on M...

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Bibliographic Details
Main Authors: Juan Xu, Nanhui Yu, Pan Zhao, Fangfang Wang, Jingcao Huang, Yushan Cui, Hong Ding, Yan Yang, Yuhan Gao, Ling Pan, Hong Chang, Yu Wu, Bing Xiang, Yuping Gong, Xiao Shuai, Li Hou, Liping Xie, Ting Niu, Ting Liu, Li Zhang, Weiping Liu, Wenyan Zhang, Ying Qu, Wei Lin, Yimin Zhu, Sha Zhao, Yuhuan Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Oncology
Subjects:
extramedullary multiple myeloma
MIF
immunohistochemistry staining
xenograft models
single-cell sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.694331/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.694331/full

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