Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice.

Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice.

Slow-twitch muscles, devoted to postural maintenance, experience atrophy and weakness during muscle disuse due to bed-rest, aging or spaceflight. These conditions impair motion activities and can have survival implications. Human and animal studies demonstrate the anabolic role of IGF-1 on skeletal...

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Bibliographic Details
Main Authors: Sabata Pierno, Giulia M Camerino, Maria Cannone, Antonella Liantonio, Michela De Bellis, Claudio Digennaro, Gianluca Gramegna, Annamaria De Luca, Elena Germinario, Daniela Danieli-Betto, Romeo Betto, Gabriella Dobrowolny, Emanuele Rizzuto, Antonio Musarò, Jean-François Desaphy, Diana Conte Camerino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3670938?pdf=render

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http://europepmc.org/articles/PMC3670938?pdf=render

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