CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway

Background. Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to inves...

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Bibliographic Details
Main Authors: Tianxin Geng, Yang Yan, Yue Zhang, Liangjie Xu, Guangyao Zang, Jin Chuan Yan
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2020/4321912