A Polymorphism at the 3'-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma

A Polymorphism at the 3'-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma

Estrogen-related genes and the fat mass and obesity-associated (FTO) gene play a critical role in estrogen metabolism, and those polymorphisms are associated with a poor prognosis in breast cancer. However, little is known about the association between these polymorphisms and the efficacy of anastro...

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Bibliographic Details
Main Authors: Qing-Yuan Zhang, Shu Zhao, Jing-Xuan Wang, Yan-Jing Li, Peng Huang, Xiao-Li Wei, Ting-Ting Zhang, Rui Xie, Heng-Heng Yuan, Wen-Jie Zhang, Hong Sui, Xiu-Wei Sun, Yu-Xian Bai, Jian-Hua Zhou, Lei Liu
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:International Journal of Molecular Sciences
Subjects:
metastatic breast carcinoma
aromatase gene
anastrozole
prognosis
polymorphism
Online Access:http://www.mdpi.com/1422-0067/14/9/18973

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http://www.mdpi.com/1422-0067/14/9/18973

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