Identification of Clostridioides difficile-Inhibiting Gut Commensals Using Culturomics, Phenotyping, and Combinatorial Community Assembly

Identification of Clostridioides difficile-Inhibiting Gut Commensals Using Culturomics, Phenotyping, and Combinatorial Community Assembly

Antibiotic treatment causes instability of gut microbiota and the loss of colonization resistance, thus allowing pathogens such as Clostridioides difficile to colonize and causing recurrent infection and mortality. Although fecal microbiome transplantation has been shown to be an effective treatment...

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Bibliographic Details
Main Authors: Sudeep Ghimire, Chayan Roy, Supapit Wongkuna, Linto Antony, Abhijit Maji, Mitchel Chan Keena, Andrew Foley, Joy Scaria
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mSystems
Subjects:
clostridium difficile
coculture
colonization resistance
culturomics
fatty acids
metagenomics
microbiome
nutrient competition
pathogen inhibition
phenotypic identification
Online Access:https://doi.org/10.1128/mSystems.00620-19

Internet

https://doi.org/10.1128/mSystems.00620-19

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