Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K/AKT and STAT3 signaling pathways in scar-forming fibroblasts.

Anti-fibrotic actions of interleukin-10 against hypertrophic scarring by activation of PI3K/AKT and STAT3 signaling pathways in scar-forming fibroblasts.

BACKGROUND: The hypertrophic scar (HS) is a serious fibrotic skin condition and a major clinical problem. Interleukin-10 (IL-10) has been identified as a prospective scar-improving compound based on preclinical trials. Our previous work showed that IL-10 has anti-fibrotic effects in transforming gro...

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Main Authors: Jihong Shi, Jun Li, Hao Guan, Weixia Cai, Xiaozhi Bai, Xiaobing Fang, Xiaolong Hu, Yaojun Wang, Hongtao Wang, Zhao Zheng, Linlin Su, Dahai Hu, Xiongxiang Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4039501?pdf=render

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http://europepmc.org/articles/PMC4039501?pdf=render

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