Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis

Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis

Glioblastoma (GBM) is the most prevalent malignant tumor in the central nervous system. Aerobic glycolysis, featured with elevated glucose consumption and lactate production, confers selective advantages on GBM by utilizing nutrients to support rapid cell proliferation and tumor growth. Pyruvate kin...

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Bibliographic Details
Main Authors: Jianshuang Guo, Qingqing Xue, Kaihui Liu, Weizhi Ge, Wenjie Liu, Jiyan Wang, Mengyi Zhang, Qiu-ying Li, Dongpo Cai, Changliang Shan, Chunze Zhang, Xinqi Liu, Jing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
dimethylaminomicheliolide
glioblastoma
PKM2 activator
aerobic glycolysis
lactate production
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00993/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00993/full

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