Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction

LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM). However, LuIII displays enhanced oncolysis compared to H-1PV and MVM, a phenotype map...

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Bibliographic Details
Main Authors: Nikéa Pittman, Adam Misseldine, Lorena Geilen, Sujata Halder, J. Kennon Smith, Justin Kurian, Paul Chipman, Mandy Janssen, Robert Mckenna, Timothy S. Baker, Anthony D’Abramo Jr., Susan Cotmore, Peter Tattersall, Mavis Agbandje-McKenna
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Viruses
Subjects:
cryo-electron microscopy
oncolytic virotherapy
Parvoviridae
structural virology
Online Access:https://www.mdpi.com/1999-4915/9/11/321

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https://www.mdpi.com/1999-4915/9/11/321

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