Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation

Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation

<p>Abstract</p> <p>Background</p> <p>2,4-Dimethoxyphenyl-<it>E</it>-4-arylidene-3-isochromanone (IK11) was previously described to induce apoptotic death of A431 tumor cells. In this report, we investigated the molecular action of IK11 in the HepG2 human hep...

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Bibliographic Details
Main Authors: Radnai Balazs, Antus Csenge, Racz Boglarka, Engelmann Peter, Priber Janos, Tucsek Zsuzsanna, Veres Balazs, Turi Zsuzsanna, Lorand Tamas, Sumegi Balazs, Gallyas Ferenc
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Molecular Cancer
Subjects:
Poly(ADP-ribose)-polymerase (PARP)
Mitogen activated protein kinase (MAPK)
c-Jun N-terminal kinase (JNK)
Protein kinase B (PKB/Akt)
Mitochondrial depolarization
Online Access:http://www.molecular-cancer.com/content/11/1/34

Internet

http://www.molecular-cancer.com/content/11/1/34

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