Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against <i>Leishmania</i> Hsp90

Design, Synthesis and In Vitro Investigation of Novel Basic Celastrol Carboxamides as Bio-Inspired Leishmanicidal Agents Endowed with Inhibitory Activity against <i>Leishmania</i> Hsp90

The natural triterpene celastrol (<b>CE</b>) is here used as lead compound for the design and synthesis of a panel of eleven <b>CE</b> carboxamides that were tested in vitro for their growth inhibitory activity against <i>Leishmania infantum</i> and <i>L.<...

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Bibliographic Details
Main Authors: Ivan Bassanini, Silvia Parapini, Erica E. Ferrandi, Elena Gabriele, Nicoletta Basilico, Donatella Taramelli, Anna Sparatore
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Biomolecules
Subjects:
celastrol
natural compounds
<i>Leishmania</i> Hsp90
Hsp90 inhibition
leishmanicidal compounds
protozoa
Online Access:https://www.mdpi.com/2218-273X/11/1/56

Internet

https://www.mdpi.com/2218-273X/11/1/56

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