Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer Patients

Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer Patients

Cell-free DNA (cfDNA) and circulating tumor cells (CTCs) exhibit great potential for therapy management in oncology. We aimed to establish a multimodal liquid biopsy strategy that is usable with minimized blood volume to deconvolute the genomic complexity of metastatic breast cancer. CTCs were isola...

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Bibliographic Details
Main Authors: Corinna Keup, Markus Storbeck, Siegfried Hauch, Peter Hahn, Markus Sprenger-Haussels, Oliver Hoffmann, Rainer Kimmig, Sabine Kasimir-Bauer
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
liquid biopsy
circulating tumor cells
cell-free DNA
circulating tumor DNA
next-generation sequencing
unique molecular indices
Online Access:https://www.mdpi.com/2072-6694/12/5/1084

Internet

https://www.mdpi.com/2072-6694/12/5/1084

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