Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells

Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells

Most patients with advanced colorectal cancer (CRC) eventually develop resistance to systemic combination therapy. miR-195-5p and miR-497-5p are downregulated in CRC tissues and associated with drug resistance. Sensitization to 5-FU, oxaliplatin, and irinotecan by transfection with miR-195-5p and mi...

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Bibliographic Details
Main Authors: Dennis Poel, Lenka N.C. Boyd, Robin Beekhof, Tim Schelfhorst, Thang V. Pham, Sander R. Piersma, Jaco C. Knol, Connie R. Jimenez, Henk M.W. Verheul, Tineke E. Buffart
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
microRNA
chemotherapy
proteomics
colorectal cancer
Online Access:https://www.mdpi.com/2073-4409/8/9/1111

Internet

https://www.mdpi.com/2073-4409/8/9/1111

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