Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency

Sirt6 regulates efficiency of mouse somatic reprogramming and maintenance of pluripotency

Abstract Background Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. It has been reported that Sirtuin 6 (Sirt6), a member of the sirtuin family of NAD+-dependent protein deac...

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Bibliographic Details
Main Authors: Peng Xu, Ting-ting Wang, Xiu-zhen Liu, Nan-Yu Wang, Li-hong Sun, Zhu-qin Zhang, Hou-zao Chen, Xiang Lv, Yue Huang, De-Pei Liu
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Stem Cell Research & Therapy
Subjects:
Mouse embryonic fibroblast
Reprogramming
Differentiation
Sirt6
Online Access:http://link.springer.com/article/10.1186/s13287-018-1109-5

Internet

http://link.springer.com/article/10.1186/s13287-018-1109-5

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