Prevalence and Atypical Clinical Characteristics of NOTCH3 Mutations Among Patients Admitted for Acute Lacunar Infarctions

Prevalence and Atypical Clinical Characteristics of NOTCH3 Mutations Among Patients Admitted for Acute Lacunar Infarctions

Objectives: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary small vessel disease, with reported frequencies of 2-5/100,000 individuals. Recently, it has been reported that some patients with NOTCH3 gene mutations show...

Full description

Bibliographic Details
Main Authors: Takashi Okada, Kazuo Washida, Kenichi Irie, Satoshi Saito, Michio Noguchi, Tsutomu Tomita, Masatoshi Koga, Kazunori Toyoda, Shuhei Okazaki, Takashi Koizumi, Ikuko Mizuta, Toshiki Mizuno, Masafumi Ihara
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
CADASIL
CADASIL scale-J
NOTCH3
R75P mutation
lacunar infarction
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00130/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2020.00130/full

Similar Items