Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Complementary NAD+ replacement strategies fail to functionally protect dystrophin-deficient muscle

Abstract Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decrease the incidence or mitigate the consequences of...

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Bibliographic Details
Main Authors: David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Skeletal Muscle
Subjects:
MDX
NAD+
CD38
NR
Eccentric
Injury
Online Access:http://link.springer.com/article/10.1186/s13395-020-00249-y

Internet

http://link.springer.com/article/10.1186/s13395-020-00249-y

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