Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model

Monoclonal Antibody Combinations Prevent Serotype A and Serotype B Inhalational Botulism in a Guinea Pig Model

Botulinum neurotoxins (BoNT) are some of the most toxic proteins known, with a human LD<sub>50</sub> of ~1 ng/kg. Equine antitoxin has a half-life in circulation of less than 1 day and is limited to a treatment rather than a prevention indication. The development of monoclonal antibodies...

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Bibliographic Details
Main Authors: Milan T. Tomic, Yero Espinoza, Zachary Martinez, Khanh Pham, Ronald R. Cobb, Doris M. Snow, Christopher G. Earnhart, Traci Pals, Emily S. Syar, Nancy Niemuth, Dean J. Kobs, Shauna Farr-Jones, James D. Marks
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Toxins
Subjects:
botulinum neurotoxin
aerosol
monoclonal antibody
guinea pig inhalation model
oligoclonal antibody
inhalational botulism
botulism
Online Access:https://www.mdpi.com/2072-6651/11/4/208

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https://www.mdpi.com/2072-6651/11/4/208

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