Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia

Neoantigen-Specific T-Cell Immune Responses: The Paradigm of NPM1-Mutated Acute Myeloid Leukemia

The C-terminal aminoacidic sequence from NPM1-mutated protein, absent in normal human tissues, may serve as a leukemia-specific antigen and can be considered an ideal target for <i>NPM1</i>-mutated acute myeloid leukemia (AML) immunotherapy. Different in silico instruments and in vitro/e...

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Bibliographic Details
Main Authors: Fabio Forghieri, Giovanni Riva, Ivana Lagreca, Patrizia Barozzi, Francesca Bettelli, Ambra Paolini, Vincenzo Nasillo, Beatrice Lusenti, Valeria Pioli, Davide Giusti, Andrea Gilioli, Corrado Colasante, Laura Galassi, Hillary Catellani, Francesca Donatelli, Annalisa Talami, Rossana Maffei, Silvia Martinelli, Leonardo Potenza, Roberto Marasca, Enrico Tagliafico, Rossella Manfredini, Tommaso Trenti, Patrizia Comoli, Mario Luppi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
<i>NPM1</i> mutation
acute myeloid leukemia
leukemia-specific neoantigen
NPM1-mutated-specific T cells
adoptive immunotherapy
immune-checkpoint inhibitors
Online Access:https://www.mdpi.com/1422-0067/22/17/9159

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https://www.mdpi.com/1422-0067/22/17/9159

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