Neurometabolite mapping highlights elevated myo-inositol profiles within the developing brain in down syndrome

Neurometabolite mapping highlights elevated myo-inositol profiles within the developing brain in down syndrome

The neurodevelopmental phenotype in Down Syndrome (DS), or Trisomy 21, is variable including a wide spectrum of cognitive impairment and a high risk of early-onset Alzheimer's disease (AD). A key metabolite of interest within the brain in DS is Myo-inositol (mIns). The NA+/mIns co-transporter i...

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Bibliographic Details
Main Authors: Prachi A. Patkee, Ana A. Baburamani, Katherine R. Long, Ralica Dimitrova, Judit Ciarrusta, Joanna Allsop, Emer Hughes, Johanna Kangas, Grainne M. McAlonan, Mary A. Rutherford, Enrico De Vita
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Neurobiology of Disease
Subjects:
Developing
Brain
Down syndrome
MR spectroscopy
Mass spectrometry
Myo-inositol
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000656

Internet

http://www.sciencedirect.com/science/article/pii/S0969996121000656

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