Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation

Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation

Abstract Background TNF-α-stimulated gene 6 (TSG-6) protein, a TNF-α-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form heavy chain-hyaluronic acid (HC-HA) complexes in pathological conditio...

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Bibliographic Details
Main Authors: Diana C. Fasanello, Jin Su, Siyu Deng, Rose Yin, Marshall J. Colville, Joshua M. Berenson, Carolyn M. Kelly, Heather Freer, Alicia Rollins, Bettina Wagner, Felipe Rivas, Adam R. Hall, Elaheh Rahbar, Paul L. DeAngelis, Matthew J. Paszek, Heidi L. Reesink
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Arthritis Research & Therapy
Subjects:
Synovial fluid
Viscosity
Microrheology
SEC-MALS
Heavy chain-hyaluronic acid
Cartilage
Online Access:https://doi.org/10.1186/s13075-021-02588-7

Internet

https://doi.org/10.1186/s13075-021-02588-7

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