Depression and Obesity in Patients With Psoriasis and Psoriatic Arthritis: Is IL-17-Mediated Immune Dysregulation the Connecting Link?

Depression and Obesity in Patients With Psoriasis and Psoriatic Arthritis: Is IL-17-Mediated Immune Dysregulation the Connecting Link?

Patients with psoriasis are frequently obese and experience anxiety or suffer from depressive disorders. The immunopathogenesis of psoriasis and indeed psoriatic arthritis is largely based on the pivotal role of IL-17/IL-23 axis, to an extent that currently monoclonal antibodies selectively inhibiti...

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Bibliographic Details
Main Authors: Efterpi Zafiriou, Athina I. Daponte, Vasileios Siokas, Christina Tsigalou, Efthymios Dardiotis, Dimitrios P. Bogdanos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
depression
IL-17
IL-23
immunity
obesity
psoriasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.699848/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.699848/full

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